Pharmacology of tolazoline.

Article Details

Citation

Ward RM

Pharmacology of tolazoline.

Clin Perinatol. 1984 Oct;11(3):703-13.

PubMed ID
6386273 [ View in PubMed
]
Abstract

Tolazoline's complex pharmacologic effects likely represent the algebraic sum of primary, secondary, and possibly tertiary interactions with histamine and adrenergic receptors. Oxygenation improves initially in the majority of neonates with PPHN treated with tolazoline. Preliminary studies of tolazoline pharmacokinetics in the newborn indicate current doses are excessive and lead to accumulation, which may contribute to adverse effects, including cardiotoxicity.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
TolazolineHistamine H2 receptorProteinHumans
Unknown
Agonist
Details