Pharmacology of tolazoline.
Article Details
- CitationCopy to clipboard
Ward RM
Pharmacology of tolazoline.
Clin Perinatol. 1984 Oct;11(3):703-13.
- PubMed ID
- 6386273 [ View in PubMed]
- Abstract
Tolazoline's complex pharmacologic effects likely represent the algebraic sum of primary, secondary, and possibly tertiary interactions with histamine and adrenergic receptors. Oxygenation improves initially in the majority of neonates with PPHN treated with tolazoline. Preliminary studies of tolazoline pharmacokinetics in the newborn indicate current doses are excessive and lead to accumulation, which may contribute to adverse effects, including cardiotoxicity.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Tolazoline Histamine H2 receptor Protein Humans UnknownAgonistDetails