Inhibition of human placental aromatase by mefloquine.

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Ayub M, Scott TA

Inhibition of human placental aromatase by mefloquine.

J Steroid Biochem. 1988 Jan;29(1):149-51.

PubMed ID

3258046 [ View in PubMed

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Abstract

Aromatase activity of human placental microsomes was inhibited competitively by the antimalarial drug, mefloquine, but not by the related drug, chloroquine. In the absence of any drug, the Km for testosterone was 47.1 +/- 2.3 nmol/l (mean +/- SD, n = 2). In the presence of chloroquine 500 mumol/l, the Km remained unchanged (47.4 +/- 1.8 nmol/l (mean +/- SD, n = 2), whereas mefloquine inhibited competitively with respect to substrate with a Ki value of 72 +/- 4.2 mumol/l (mean +/- SD, n = 2).

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Mefloquine	Cytochrome P450 19A1	Protein	Humans	Unknown	Inhibitor	Details