The penetration of local anesthetics into phosphatidylcholine monolayers.

Article Details

Citation

Copy to clipboard

Hendrickson HS

The penetration of local anesthetics into phosphatidylcholine monolayers.

J Lipid Res. 1976 Jul;17(4):393-8.

PubMed ID

133194 [ View in PubMed

]

Abstract

The penetration of tetracaine into monolayers of phosphatidylcholine and trioctanoin at different surface pressures, and the penetration of dibucaine, tetracaine, butacaine, lidocaine, and procaine into monolayers of didecanoylphosphatidylcholine at II = 10 mN/m was determined by the use of a modified Gibbs adsorption equation. These data were shown to fit a geometric model and compared favorably with data determined by a method based on the geometric model. The penetration of tetracaine into phosphatidylcholine monolayers was pressure dependent. At II = 10 mN/m, the local anesthetics penetrate into a phosphatidycholine monolayer in the order: dibucaine greater than tetracaine greater than butacaine greater than lidocaine greater than procaine. This correlates with their potencies in blocking nerve conduction and inhibiting phospholipase A2.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Procaine	Cytosolic phospholipase A2	Protein	Humans	Unknown	Inhibitor	Details