Highly potent PDE4 inhibitors with therapeutic potential.

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Ochiai H, Ohtani T, Ishida A, Kusumi K, Kato M, Kohno H, Kishikawa K, Obata T, Nakai H, Toda M

Highly potent PDE4 inhibitors with therapeutic potential.

Bioorg Med Chem Lett. 2004 Jan 5;14(1):207-10.

PubMed ID
14684329 [ View in PubMed
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Abstract

Based on the hypothesis that the dose-limiting side effects of PDE4 inhibitors could be mediated via the central nervous system (CNS), design and synthesis of a hydrophilic analogue is considered to be one approach to improving the side-effect profile of Ariflo 1. Water-soluble piperidine derivatives were found to possess therapeutic potential.

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