The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
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Skellern GG, Knight BI, Low CK, Alexander WD, McLarty DG, Kalk WJ
The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
Br J Clin Pharmacol. 1980 Feb;9(2):137-43. doi: 10.1111/j.1365-2125.1980.tb05823.x.
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- 7356900 [ View in PubMed]
- Abstract
1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.
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