ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later
Article Details
- CitationCopy to clipboard
Burch HB, Cooper DS
ANNIVERSARY REVIEW: Antithyroid drug therapy: 70 years later
Eur J Endocrinol. 2018 Oct 12;179(5):R261-R274. doi: 10.1530/EJE-18-0678.
- PubMed ID
- 30320502 [ View in PubMed]
- Abstract
The thionamide antithyroid drugs were discovered in large part following serendipitous observations by a number of investigators in the 1940s who found that sulfhydryl-containing compounds were goitrogenic in animals. This prompted Prof. Edwin B Astwood to pioneer the use of these compounds to treat hyperthyroidism in the early 1940s and to develop the more potent and less toxic drugs that are used today. Despite their simple molecular structure and ease of use, many uncertainties remain, including their mechanism(s) of action, clinical role, optimal use in pregnancy and the prediction and prevention of rare but potentially life-threatening adverse reactions. In this review, we summarize the history of the development of these drugs and outline their current role in the clinical management of patients with hyperthyroidism.
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Methimazole Thyroid peroxidase Protein Humans YesSubstrateInhibitorDetails