Should we stop prescribing metoclopramide as a prokinetic drug in critically ill patients?

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van der Meer YG, Venhuizen WA, Heyland DK, van Zanten AR

Should we stop prescribing metoclopramide as a prokinetic drug in critically ill patients?

Crit Care. 2014 Sep 23;18(5):502. doi: 10.1186/s13054-014-0502-4.

PubMed ID
25672546 [ View in PubMed
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Abstract

Regulatory agencies in North America and Europe recently re-evaluated the safety of metoclopramide. This re-evaluation resulted in recommendations and restrictions in order to minimise the risk of neurological and other adverse reactions associated with the use of metoclopramide. In the ICU, off-label prescription of metoclopramide is common. We have reviewed the evidence for safety, effectiveness and dosing of metoclopramide in critically ill patients. Furthermore, tachyphylaxis is addressed and alternatives are summarised. Finally, recommendations are presented not to abandon use of metoclopramide in ICU patients, because metoclopramide is considered effective in enhancing gastric emptying and facilitating early enteral nutrition.

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