Hydrochlorothiazide

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Herman LL, Bashir K

Hydrochlorothiazide

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PubMed ID
28613517 [ View in PubMed
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Abstract

Hydrochlorothiazide is a thiazide-type diuretic which has been used clinically for more than half a century. The drug has been widely used to treat hypertension globally and is relatively very safe. Hydrochlorothiazide acts on the distal convoluted tubules and inhibits the sodium chloride co-transporter system. This action leads to a diuretic action and loss of potassium in the urine. The half-life of hydrochlorothiazide varies from 6 to 12 hours. Of the thiazide diuretics, hydrochlorothiazide is the most frequently used for the treatment of hypertension. Unfortunately, over the past decade, the use of hydrochlorothiazide has been declining, and it is being replaced by the angiotensin-converting enzyme inhibitors, which overall are far more effective and have fewer adverse effects.[1][2][3]

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