The physiological and pharmacological roles of cytochrome P450 isoenzymes.

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Chang GW, Kam PC

The physiological and pharmacological roles of cytochrome P450 isoenzymes.

Anaesthesia. 1999 Jan;54(1):42-50. doi: 10.1046/j.1365-2044.1999.00602.x.

PubMed ID

10209369 [ View in PubMed

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Abstract

The cytochrome P450 isoenzymes are a superfamily of haemoprotein enzymes that catalyse the metabolism of a large number of endogenous and exogenous compounds. Recently, the cytochrome isoenzymes have been shown to be important in the synthesis of steroid hormones and bile acids, the arachidonic acid cascade and in central nervous function. These enzymes are a major determinant of the pharmacokinetic behaviour of numerous drugs. Furthermore, alterations in cytochrome P450 activity have been implicated in some diseases.

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Methoxyflurane	Cytochrome P450 2E1	Protein	Humans	Unknown	Substrate	Details