Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

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Vong K, Auclair K

Understanding and overcoming aminoglycoside resistance caused by N-6'-acetyltransferase.

Medchemcomm. 2012 Apr 1;3(4):397-407. doi: 10.1039/C2MD00253A.

PubMed ID

28018574 [ View in PubMed

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Abstract

Aminoglycosides occupy a special niche amongst antibiotics in part because of their broad spectrum of action. Bacterial resistance is however menacing to render these drugs obsolete. A significant amount of work has been devoted to understand and overcome aminoglycoside resistance. This mini-review will discuss aminoglycoside-modifying enzymes (AMEs), with a special emphasis on the efforts to comprehend and block resistance caused by aminoglycoside 6'-N-acetyltransferase (AAC(6')).

DrugBank Data that Cites this Article

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Ribostamycin	Aminoglycoside 2'-N-acetyltransferase	Protein	Mycobacterium tuberculosis	Unknown	Substrate	Details