Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways.

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Jain M

Quetiapine associated Central Serous Chorioretinopathy: Implicit role of serotonin and dopamine pathways.

Indian J Ophthalmol. 2019 Feb;67(2):292-294. doi: 10.4103/ijo.IJO_929_18.

PubMed ID

30672500 [ View in PubMed

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Abstract

A 30-year-old insomniac, an off-label user of quetiapine, presented with blurring of central vision, eventually diagnosed as central serous chorioretinopathy. A potential association was suspected based on the drug's actions on the autonomic nervous system. He showed improvement on drug withdrawal; then he unwittingly resumed quetiapine and had a recurrence. Possible underlying mechanisms that include alteration in choroidal perfusion through serotonin and dopamine receptors are discussed. Although retinal vein occlusions and pigment epithelial detachment have been described with quetiapine, to the author's knowledge, this is the first case report of quetiapine-associated central serous chorioretinopathy.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Quetiapine	Dopamine D5 receptor	Protein	Humans	Unknown	Ligand	Details