Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine.
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Haegele KD, Skrdlant HB, Talseth T, McNay JL, Shepherd AM, Clementi WA
Quantitative analysis of hydralazine pyruvic acid hydrazone, the major plasma metabolite of hydralazine.
J Chromatogr. 1980 Jan 4;187(1):171-9. doi: 10.1016/s0021-9673(00)87883-8.
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- 7358814 [ View in PubMed]
- Abstract
A specific, high-performance liquid chromatographic technique for the measurement of hydralazine pyruvic acid hydrazone is described. This method utilized reversed-phase chromatography for the separation of this hydrophilic metabolite of hydralazine from other fluid constituents present in serum, plasma, or urine of human volunteers and rabbits receiving hydralazine. Detection of the compound of interest is accomplished spectrophotometrically at 250 nm.
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