Phenotypic Assessment and the Discovery of Topiramate.
Article Details
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Maryanoff BE
Phenotypic Assessment and the Discovery of Topiramate.
ACS Med Chem Lett. 2016 Jun 13;7(7):662-5. doi: 10.1021/acsmedchemlett.6b00176. eCollection 2016 Jul 14.
- PubMed ID
- 27437073 [ View in PubMed]
- Abstract
The role of phenotypic assessment in drug discovery is discussed, along with the discovery and development of TOPAMAX (topiramate), a billion-dollar molecule for the treatment of epilepsy and migraine.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Topiramate Voltage-dependent R-type calcium channel (Protein Group) Protein group Humans UnknownAntagonistDetails