Phenotypic Assessment and the Discovery of Topiramate.

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Maryanoff BE

Phenotypic Assessment and the Discovery of Topiramate.

ACS Med Chem Lett. 2016 Jun 13;7(7):662-5. doi: 10.1021/acsmedchemlett.6b00176. eCollection 2016 Jul 14.

PubMed ID

27437073 [ View in PubMed

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Abstract

The role of phenotypic assessment in drug discovery is discussed, along with the discovery and development of TOPAMAX (topiramate), a billion-dollar molecule for the treatment of epilepsy and migraine.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Topiramate	Voltage-dependent R-type calcium channel (Protein Group)	Protein group	Humans	Unknown	Antagonist	Details