Binding of chlorpheniramine enantiomers to human plasma proteins.
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Hiep BT, Gimenez F, Khanh VU, Hung NK, Thuillier A, Farinotti R, Fernandez C
Binding of chlorpheniramine enantiomers to human plasma proteins.
Chirality. 1999;11(5-6):501-4.
- PubMed ID
- 10368923 [ View in PubMed]
- Abstract
The in vitro binding of RS-chlorpheniramine to human proteins was studied by equilibrium dialysis. The binding to total plasma proteins and to individual albumin and alpha-glycoprotein acid is stereoselective. (+)S-chlorpheniramine is more extensively bound than its antipode to total plasma proteins (38% vs. 23%), to albumin (20% vs. 15%) and to alpha-glycoprotein acid (23% vs. 5%).
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