Phenytoin Toxicity
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Iorga A, Horowitz BZ
Phenytoin Toxicity
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- PubMed ID
- 29494051 [ View in PubMed]
- Abstract
Since its discovery in 1908, phenytoin has become one of the most well-studied anticonvulsants. With an average monthly cost of $30, it has also become one of the most widely used anticonvulsants, listed on the World Health Organization's List of Essential Medicines. However, with its narrow therapeutic index and its pervasive daily use, considering potential phenytoin overdose or toxicity from chronic use is key to early management and prevention of further toxicity.[1][2][3]
DrugBank Data that Cites this Article
- Drugs
- Drug Interactions
Drugs Interaction Integrate drug-drug
interactions in your softwareCyclosporinePhenytoin The serum concentration of Cyclosporine can be decreased when it is combined with Phenytoin. CyclosporineFosphenytoin The serum concentration of Cyclosporine can be decreased when it is combined with Fosphenytoin. FosphenytoinOmeprazole The serum concentration of Fosphenytoin can be increased when it is combined with Omeprazole. FosphenytoinEsomeprazole The serum concentration of Fosphenytoin can be increased when it is combined with Esomeprazole. PhenytoinOmeprazole The serum concentration of Phenytoin can be increased when it is combined with Omeprazole.