Medicinal Cannabis-Potential Drug Interactions.

Article Details

Citation

Alsherbiny MA, Li CG

Medicinal Cannabis-Potential Drug Interactions.

Medicines (Basel). 2018 Dec 23;6(1). pii: medicines6010003. doi: 10.3390/medicines6010003.

PubMed ID
30583596 [ View in PubMed
]
Abstract

The endocannabinoids system (ECS) has garnered considerable interest as a potential therapeutic target in various carcinomas and cancer-related conditions alongside neurodegenerative diseases. Cannabinoids are implemented in several physiological processes such as appetite stimulation, energy balance, pain modulation and the control of chemotherapy-induced nausea and vomiting (CINV). However, pharmacokinetics and pharmacodynamics interactions could be perceived in drug combinations, so in this short review we tried to shed light on the potential drug interactions of medicinal cannabis. Hitherto, few data have been provided to the healthcare practitioners about the drug(-)drug interactions of cannabinoids with other prescription medications. In general, cannabinoids are usually well tolerated, but bidirectional effects may be expected with concomitant administered agents via affected membrane transporters (Glycoprotein p, breast cancer resistance proteins, and multidrug resistance proteins) and metabolizing enzymes (Cytochrome P450 and UDP-glucuronosyltransferases). Caution should be undertaken to closely monitor the responses of cannabis users with certain drugs to guard their safety, especially for the elderly and people with chronic diseases or kidney and liver conditions.

DrugBank Data that Cites this Article

Drugs
Drug Enzymes
DrugEnzymeKindOrganismPharmacological ActionActions
CannabidiolCytochrome P450 1A1ProteinHumans
Unknown
Inhibitor
Details
CannabidiolCytochrome P450 1A2ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
CannabidiolCytochrome P450 1B1ProteinHumans
Unknown
Inhibitor
Details
CannabidiolCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
CannabidiolCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabidiolCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabidiolCytochrome P450 2C9ProteinHumans
No
Substrate
Inhibitor
Details
CannabidiolCytochrome P450 2D6ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabidiolCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabidiolUDP-glucuronosyltransferase 1-9ProteinHumans
No
Substrate
Inhibitor
Details
CannabidiolUDP-glucuronosyltransferase 2B7ProteinHumans
No
Substrate
Inhibitor
Details
CannabinolCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
CannabinolCytochrome P450 2B6ProteinHumans
Unknown
Inhibitor
Details
CannabinolCytochrome P450 2C9ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabinolCytochrome P450 2D6ProteinHumans
Unknown
Inhibitor
Details
CannabinolCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabinolUDP-glucuronosyltransferase 1-7ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabinolUDP-glucuronosyltransferase 1-8ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabinolUDP-glucuronosyltransferase 1-9ProteinHumans
Unknown
Substrate
Inhibitor
Details
CannabinolUDP-glucuronosyltransferase 2B7ProteinHumans
Unknown
Substrate
Inducer
Details
DronabinolCytochrome P450 1A1ProteinHumans
No
Inhibitor
Inducer
Details
DronabinolCytochrome P450 2A6ProteinHumans
No
Inhibitor
Details
DronabinolCytochrome P450 2B6ProteinHumans
No
Inhibitor
Details
DronabinolCytochrome P450 2C9ProteinHumans
No
Substrate
Inhibitor
Inducer
Details
DronabinolCytochrome P450 2D6ProteinHumans
No
Inhibitor
Details
DronabinolCytochrome P450 3A4ProteinHumans
No
Substrate
Inhibitor
Details
Medical CannabisCytochrome P450 1A1ProteinHumans
Unknown
Inhibitor
Inducer
Details
Medical CannabisCytochrome P450 1A2ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
Medical CannabisCytochrome P450 1B1ProteinHumans
Unknown
Inhibitor
Details
Medical CannabisCytochrome P450 2A6ProteinHumans
Unknown
Inhibitor
Details
Medical CannabisCytochrome P450 2B6ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
Medical CannabisCytochrome P450 2C19ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisCytochrome P450 2C8ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisCytochrome P450 2C9ProteinHumans
No
Substrate
Inhibitor
Inducer
Details
Medical CannabisCytochrome P450 2D6ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisCytochrome P450 3A4ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisUDP-glucuronosyltransferase 1-7ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisUDP-glucuronosyltransferase 1-8ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisUDP-glucuronosyltransferase 1-9ProteinHumans
Unknown
Substrate
Inhibitor
Details
Medical CannabisUDP-glucuronosyltransferase 2B7ProteinHumans
Unknown
Substrate
Inhibitor
Inducer
Details
Drug Transporters
DrugTransporterKindOrganismPharmacological ActionActions
DronabinolP-glycoprotein 1ProteinHumans
Unknown
Inhibitor
Details