A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype.
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Marez-Allorge D, Ellis SW, Lo Guidice JM, Tucker GT, Broly F
A rare G2061 insertion affecting the open reading frame of CYP2D6 and responsible for the poor metabolizer phenotype.
Pharmacogenetics. 1999 Jun;9(3):393-6.
- PubMed ID
- 10471072 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Pharmaco-genomics
Drug Interacting Gene/Enzyme Allele name Genotypes Defining change(s) Type(s) Description Details Metoprolol Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
ADR Inferred Increased risk of slow heart rate (bradycardia) Details Venlafaxine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea Details Codeine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements Details Amitriptyline Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Imipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Dextromethorphan Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements Details Nortriptyline Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Tamoxifen Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor response to drug treatment, shorter time to relapse Details Desipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Clomipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Atomoxetine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*20 Not Available - 1973_1974insG (rs72549354)
Effect Inferred Poor drug metabolizer, increased side effects. Details