Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.
Article Details
- CitationCopy to clipboard
Gaedigk A, Frank D, Fuhr U
Identification of a novel non-functional CYP2D6 allele, CYP2D6*69, in a Caucasian poor metabolizer individual.
Eur J Clin Pharmacol. 2009 Jan;65(1):97-100. doi: 10.1007/s00228-008-0559-6. Epub 2008 Sep 17.
- PubMed ID
- 18797858 [ View in PubMed]
- Abstract
Not Available
DrugBank Data that Cites this Article
- Pharmaco-genomics
Drug Interacting Gene/Enzyme Allele name Genotypes Defining change(s) Type(s) Description Details Metoprolol Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
ADR Inferred Increased risk of slow heart rate (bradycardia) Details Venlafaxine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, nausea, vomiting and diarrhea Details Codeine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements Details Amitriptyline Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Imipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Dextromethorphan Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements Details Nortriptyline Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Tamoxifen Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor response to drug treatment, shorter time to relapse Details Desipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Clomipramine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, lower dose requirements, higher risk for adverse side effects Details Atomoxetine Cytochrome P450 2D6
Gene symbol: CYP2D6
UniProt: P10635CYP2D6*69 Not Available - 2988G>A (rs28371725)
- -1426C>T
- -1235A>G
Effect Inferred Poor drug metabolizer, increased side effects. Details