Pharmacokinetics of primidone elimination by uremic patients.

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Citation

Lee CS, Marbury TC, Perchalski RT, Wilder BJ

Pharmacokinetics of primidone elimination by uremic patients.

J Clin Pharmacol. 1982 Jul;22(7):301-8. doi: 10.1002/j.1552-4604.1982.tb02679.x.

PubMed ID
7107978 [ View in PubMed
]
Abstract

The hemodialyzability of primidone was investigated in four patients on long-term hemodialysis. Primidone, 500 or 250 mg, was given orally 2 hours before hemodialysis. Blood and dialyzate samples were collected periodically during the 4-hour dialysis and measured by gas-liquid chromatography and high-performance liquid chromatography for primidone. Dialysis clearance calculated by the instantaneous dialyzate method averaged 97.7 ml/min, which is considerably greater than the metabolic clearance of 30 ml/min for the drug. The extraction efficiency of the hollow-fiber dialyzers averaged 40.2 pr cent for plasma samples. A mean of 31.7 per cent of the administered dose of primidone was removed during hemodialysis. The half-life was 5.1 hours in our patients during hemodialysis, a nearly two-thirds reduction of the 13.9-hour half-life calculated in uremic patients. Because of the reduction in elimination half-life, greater dialysis clearance than metabolic clearance, high extraction efficiency, and significant drug removal during dialysis, we conclude that primidone is dialyzable.

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