Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.

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van Heijst AN, de Jong W, Seldenrijk R, van Dijk A

Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.

J Toxicol Clin Toxicol. 1983 Jun;20(4):307-18. doi: 10.3109/15563658308990598.

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6655772 [ View in PubMed
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Abstract

The present paper describes a patient who was in danger of dying from a massive primidone overdose. She was comatose, hypotensive and in acute renal failure with crystalluria. Because of her clinical condition and high plasma primidone level (209 mg/l) haemoperfusion was instituted. Both the calculated drug clearances and the remarkable improvement in the patient's clinical condition suggest that haemoperfusion was very effective.

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