Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics.

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Fouda HG, Hobbs DC, Stambaugh JE

Sensitive assay for determination of hydroxyzine in plasma and its human pharmacokinetics.

J Pharm Sci. 1979 Nov;68(11):1456-8. doi: 10.1002/jps.2600681134.

PubMed ID
512901 [ View in PubMed
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Abstract

An assay suitable for hydroxyzine determination in human plasma following therapeutic doses was developed. The method involves GLC and chemical-ionization mass spectrometry of the acetate derivatives of hydroxyzine and of a pentadeuterated analog internal standard. Following administration of 100-mg single oral doses to normal male volunteers, peak plasma concentrations of approximately 80 ng/ml were observed; the half-life of drug removal was approximately 3 hr.

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