Cytochrome P450 2C9-CYP2C9.

Article Details

Citation

Copy to clipboard

Van Booven D, Marsh S, McLeod H, Carrillo MW, Sangkuhl K, Klein TE, Altman RB

Cytochrome P450 2C9-CYP2C9.

Pharmacogenet Genomics. 2010 Apr;20(4):277-81. doi: 10.1097/FPC.0b013e3283349e84.

PubMed ID

20150829 [ View in PubMed

]

Abstract

Not Available

DrugBank Data that Cites this Article

Drug Interactions

• Approved
• Vet approved
• Nutraceutical
• Illicit
• Withdrawn
• Investigational
• Experimental
• All Drugs

Drugs	Interaction
Integrate drug-drug interactions in your software
Abrocitinib Efavirenz	The metabolism of Abrocitinib can be decreased when combined with Efavirenz.
Abrocitinib Troglitazone	The metabolism of Abrocitinib can be decreased when combined with Troglitazone.
Abrocitinib Valproic acid	The metabolism of Abrocitinib can be decreased when combined with Valproic acid.
Abrocitinib Imatinib	The metabolism of Abrocitinib can be decreased when combined with Imatinib.
Abrocitinib Mifepristone	The metabolism of Abrocitinib can be decreased when combined with Mifepristone.

Pharmaco-genomics

Drug	Interacting Gene/Enzyme	Allele name	Genotypes	Defining change(s)	Type(s)	Description	Details
Phenytoin	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Celecoxib	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Warfarin	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Clopidogrel	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements, higher risk for drug-drug interactions	Details
Acetylsalicylic acid	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Glipizide	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Tolbutamide	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, lower dose requirements	Details
Acenocoumarol	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	Effect Inferred	Poor drug metabolizer, associated with lower dose requirement.	Details
Phenprocoumon	Cytochrome P450 2C9 Gene symbol: CYP2C9 UniProt: P11712	CYP2C9*4	Not Available	1076T>C (rs56165452)	ADR Inferred	Associated with delayed stabilization. If carrier of rs9934438 as well, increased risk of severe overanticoagulation.	Details