Cytochrome P450 2C9-CYP2C9.

Article Details

Citation

Van Booven D, Marsh S, McLeod H, Carrillo MW, Sangkuhl K, Klein TE, Altman RB

Cytochrome P450 2C9-CYP2C9.

Pharmacogenet Genomics. 2010 Apr;20(4):277-81. doi: 10.1097/FPC.0b013e3283349e84.

PubMed ID
20150829 [ View in PubMed
]
Abstract

Not Available

DrugBank Data that Cites this Article

Drug Interactions
DrugsInteraction
Abrocitinib
Efavirenz
The metabolism of Abrocitinib can be decreased when combined with Efavirenz.
Abrocitinib
Troglitazone
The metabolism of Abrocitinib can be decreased when combined with Troglitazone.
Abrocitinib
Valproic acid
The metabolism of Abrocitinib can be decreased when combined with Valproic acid.
Abrocitinib
Imatinib
The metabolism of Abrocitinib can be decreased when combined with Imatinib.
Abrocitinib
Mifepristone
The metabolism of Abrocitinib can be decreased when combined with Mifepristone.
Abrocitinib
Felbamate
The metabolism of Abrocitinib can be decreased when combined with Felbamate.
Abrocitinib
Amiodarone
The metabolism of Abrocitinib can be decreased when combined with Amiodarone.
Abrocitinib
Iproniazid
The metabolism of Abrocitinib can be decreased when combined with Iproniazid.
Abrocitinib
Medical Cannabis
The metabolism of Abrocitinib can be decreased when combined with Medical Cannabis.
Abrocitinib
Fluconazole
The metabolism of Abrocitinib can be decreased when combined with Fluconazole.
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Pharmaco-genomics
DrugInteracting Gene/EnzymeAllele nameGenotypesDefining change(s)Type(s)DescriptionDetails
PhenytoinCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
CelecoxibCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
WarfarinCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
ClopidogrelCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirements, higher risk for drug-drug interactionsDetails
Acetylsalicylic acidCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
GlipizideCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
TolbutamideCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, lower dose requirementsDetails
AcenocoumarolCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableEffect InferredPoor drug metabolizer, associated with lower dose requirement.Details
PhenprocoumonCytochrome P450 2C9
Gene symbol: CYP2C9
UniProt: P11712
CYP2C9*4Not AvailableADR InferredAssociated with delayed stabilization. If carrier of rs9934438 as well, increased risk of severe overanticoagulation.Details