Estrogen receptors alpha (ERalpha) and beta (ERbeta): subtype-selective ligands and clinical potential.

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Paterni I, Granchi C, Katzenellenbogen JA, Minutolo F

Estrogen receptors alpha (ERalpha) and beta (ERbeta): subtype-selective ligands and clinical potential.

Steroids. 2014 Nov;90:13-29. doi: 10.1016/j.steroids.2014.06.012. Epub 2014 Jun 24.

PubMed ID

24971815 [ View in PubMed

]

Abstract

Estrogen receptors alpha (ERalpha) and beta (ERbeta) are nuclear transcription factors that are involved in the regulation of many complex physiological processes in humans. Modulation of these receptors by prospective therapeutic agents is currently being considered for prevention and treatment of a wide variety of pathological conditions, such as, cancer, metabolic and cardiovascular diseases, neurodegeneration, inflammation, and osteoporosis. This review provides an overview and update of compounds that have been recently reported as modulators of ERs, with a particular focus on their potential clinical applications.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Estradiol	Estrogen receptor alpha	Protein	Humans	Yes	Agonist	Details
Estradiol	Estrogen receptor beta	Protein	Humans	Yes	Agonist	Details