A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism.

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Citation

Colucci P, Yue CS, Ducharme M, Benvenga S

A Review of the Pharmacokinetics of Levothyroxine for the Treatment of Hypothyroidism.

Eur Endocrinol. 2013 Mar;9(1):40-47. doi: 10.17925/EE.2013.09.01.40. Epub 2013 Mar 15.

PubMed ID
30349610 [ View in PubMed
]
Abstract

Thyroxine hormone has been recognised since the early part of the nineteenth century and levothyroxine has been available since the mid-nineteenth century as a replacement for deficient thyroid hormones. While levothyroxine remains the staple treatment for hypothyroidism even to this day, its optimal use can be challenging. As is often the case with older drugs, the pharmacokinetics of levothyroxine is often under-appreciated or misunderstood and many factors influence the optimal dosing of levothyroxine. This article will review the pharmacokinetics of levothyroxine in the treatment of hypothyroidism and highlight major concepts that should aid both clinicians and researchers.

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