Metabolism of Thyroid Hormone

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Peeters RP, Visser TJ

Metabolism of Thyroid Hormone

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PubMed ID

25905401 [ View in PubMed

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Abstract

Thyroid hormone is indispensable for normal development and metabolism of most cells and tissues. Thyroid hormones are metabolized by different pathways: glucuronidation, sulfation, and deiodination, the latter being the most important. Three enzymes catalyzing deiodination have been identified, called type 1 (D1), type 2 (D2) and type 3 (D3) iodothyronine deiodinases. D1 and D2 have outer ring deiodinase activity, converting the prohormone T4 to its bioactive form T3 and degrading rT3 to 3,3'-T2. D3 has inner ring deiodinase activity and degrades T4 to rT3 and T3 to 3,3'-T2. D1 is largely expressed in liver and kidney. Its main role is clearance of rT3 from the circulation and it also contributes to production of plasma T3. D2 is importantly expressed in the central nervous system, pituitary, brown adipose tissue and muscle and, generally, its expression reciprocally responds to changes in thyroid state. D2 serves to adapt cellular thyroid state to changing physiological needs. D3 is importantly expressed in fetal tissues and in adult brain tissue. In addition, D3 can be re-expressed under certain pathological conditions such as critical illness or in specific cancers. In recent years, the paradigm has evolved that D2 and D3 can locally modify thyroid hormone bioactivity independent of serum thyroid hormone concentrations. Its physiological relevance has been shown in various developmental and regenerative conditions. Future studies may reveal if modifying (local) deiodinase activity can be of use under certain circumstances. For complete coverage of all related areas of Endocrinology, please see our online FREE web-book, www.endotext.org. and WWW.THYROIDMANAGER.ORG.

DrugBank Data that Cites this Article

Drugs

Thyroid, porcine

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Thyroid, porcine	Estrogen sulfotransferase	Protein	Humans	Unknown	Substrate	Details
Thyroid, porcine	Sulfotransferase 1A1	Protein	Humans	Unknown	Substrate	Details
Thyroid, porcine	Sulfotransferase 1A2	Protein	Humans	Unknown	Substrate	Details
Thyroid, porcine	Sulfotransferase 1A3/1A4	Protein	Humans	Unknown	Substrate	Details
Thyroid, porcine	Sulfotransferase 1C2	Protein	Humans	Unknown	Substrate	Details
Thyroid, porcine	Sulfotransferase family cytosolic 1B member 1	Protein	Humans	Unknown	Substrate	Details