Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.

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Gibaldi M

Comparison of observed and predicted bioavailability of nortriptyline in humans following oral administration.

J Pharm Sci. 1975 Jun;64(6):1036-7. doi: 10.1002/jps.2600640635.

PubMed ID
1133723 [ View in PubMed
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Abstract

The first-pass equation based on the dose, hepatic blood flow, and total area under the plasma level-time curve after oral administration was used retrospectively to predict the bioavailability of nortriptyline after oral administration of 1 mg/kg-single oral doses to monozygotic and dizygotic twin pairs. The predicted values of bioavailability ranged from 45 to 85%, consistent with experimentally derived estimates of nortriptyline availability.

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