Inhibition of P-glycoprotein by psychotherapeutic drugs in a canine cell model.

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Schrickx JA, Fink-Gremmels J

Inhibition of P-glycoprotein by psychotherapeutic drugs in a canine cell model.

J Vet Pharmacol Ther. 2014 Oct;37(5):515-7. doi: 10.1111/jvp.12111. Epub 2014 Mar 7.

PubMed ID

24602126 [ View in PubMed

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Abstract

Drug-drug interactions related to long-term therapies are of increasing concern. Psychotherapeutic drugs, licensed for the use in dogs for the management of separation anxiety and other behavioural disorders, are examples of drugs used in long-term therapies. In an in vitro system with canine P-glycoprotein (P-gp) expressing cell lines, three psychotherapeutic drugs with a different mode of action were tested for their ability to inhibit the canine multidrug transporter P-gp. At 10 mum, the selective serotonin reuptake inhibitor fluoxetine and the tricyclic antidepressant clomipramine inhibited P-gp for 41% and 59%, respectively. In contrast, selegeline did not inhibit the function of the canine P-gp.

DrugBank Data that Cites this Article

Drug Transporters

Drug	Transporter	Kind	Organism	Pharmacological Action	Actions
Clomipramine	P-glycoprotein 1	Protein	Humans	Unknown	Inhibitor	Details