Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application.

Article Details

Citation

Mianehrow H, Moghadam MH, Sharif F, Mazinani S

Graphene-oxide stabilization in electrolyte solutions using hydroxyethyl cellulose for drug delivery application.

Int J Pharm. 2015 Apr 30;484(1-2):276-82. doi: 10.1016/j.ijpharm.2015.02.069. Epub 2015 Feb 28.

PubMed ID
25735667 [ View in PubMed
]
Abstract

Stabilization of graphene oxide (GO) in physiological solution is performed using hydroxyethyl cellulose (HEC) to make the resultant nanohybrid suitable for targeted drug delivery purposes. Short and long term stability of GO suspensions with different ionic strengths were assessed using ultraviolet-visible spectroscopy (UV-vis), atomic force microscopy (AFM) and zeta potential measurements. Results depicted that HEC effectively stabilized GO in electrolyte solutions and the mechanism of stabilization appeares to be depended on HEC content. Drug loading and release behavior of folic acid (FA) as a model drug, from GO-HEC nanohybrid were studied to assess its application in drug delivery systems. Results showed the nanohybrid could be highly loaded by folic acid. Moreover, HEC content in the nanohybrid played an important role in final application to make it applicable either as a carrier for controllable drug release or as a folate-targeted drug carrier. In addition, according to cytotoxicity results, the nanohybrid showed good biocompatibility which indeed confirms its potential application as a drug carrier.

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