Characterization of chloroquine plasma protein binding in man.

Article Details

Citation
Copy to clipboard

Walker O, Birkett DJ, Alvan G, Gustafsson LL, Sjoqvist F

Characterization of chloroquine plasma protein binding in man.

Br J Clin Pharmacol. 1983 Mar;15(3):375-7. doi: 10.1111/j.1365-2125.1983.tb01513.x.

PubMed ID
6849768 [ View in PubMed
]
Abstract

Chloroquine protein binding was determined by equilibrium dialysis of purified plasma proteins and plasma samples from 20 healthy subjects and 14 patients with rheumatoid arthritis. The mean binding was 61 +/- 9% in plasma from healthy subjects (range 46-74%) and 64 +/- 7% in plasma from rheumatoid arthritis patients (range 55-79%). Albumin and alpha 1-acid glycoprotein at physiological concentrations bound chloroquine to an approximately equal extent. Protein binding is unlikely to be an important determinant of chloroquine pharmacokinetics or response.

DrugBank Data that Cites this Article

Drugs