Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Article Details
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Valles AS, Garbus I, Barrantes FJ
Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.
Neuroreport. 2007 Jan 8;18(1):45-50. doi: 10.1097/01.wnr.0000246323.66438.94.
- PubMed ID
- 17259859 [ View in PubMed]
- Abstract
Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Lamotrigine Acetylcholine receptor subunit alpha Protein Humans UnknownInhibitorDetails