Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.

Article Details

Citation

Valles AS, Garbus I, Barrantes FJ

Lamotrigine is an open-channel blocker of the nicotinic acetylcholine receptor.

Neuroreport. 2007 Jan 8;18(1):45-50. doi: 10.1097/01.wnr.0000246323.66438.94.

PubMed ID
17259859 [ View in PubMed
]
Abstract

Lamotrigine is an antiepileptic drug employed in the treatment of partial epilepsies. We studied its possible interaction with channels other than its known therapeutic target, the voltage-gated sodium channel, using the adult muscle nicotinic acetylcholine receptor as a model system. At the single-channel level, lamotrigine caused a dose-dependent (a) diminution in mean open time, (b) increase in mean burst duration and (c) increase in the area of a new closed-time component. A simple linear channel blocking mechanism accounts for these results. Thus, lamotrigine exerts a blocking action on the muscle nicotinic acetylcholine receptor.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
LamotrigineAcetylcholine receptor subunit alphaProteinHumans
Unknown
Inhibitor
Details