The binding of ascorbate to bovine serum albumin.

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Oelrichs BA, Kratzing CC, Kelly JD, Winzor DJ

The binding of ascorbate to bovine serum albumin.

Int J Vitam Nutr Res. 1984;54(1):61-4.

PubMed ID

6735617 [ View in PubMed

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Abstract

Ultrafiltration has been used to investigate the interaction of ascorbate with bovine serum albumin in 0.1 M sodium phosphate buffer, pH 6.5. The results are interpreted in terms of the binding of ascorbate to four equivalent and independent protein sites, governed by an intrinsic association constant of 2 600 +/- 700 M-1 at 20 degrees C, thereby providing evidence for specificity of the interaction over a range of vitamin concentration (0.08-1.5 mM) pertinent to the physiological situation.

DrugBank Data that Cites this Article

Drug Carriers

Drug	Carrier	Kind	Organism	Pharmacological Action	Actions
Ascorbic acid	Serum albumin	Protein	Humans	Unknown	Binder	Details