Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues.

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Belyaeva OV, Kedishvili NY

Human pancreas protein 2 (PAN2) has a retinal reductase activity and is ubiquitously expressed in human tissues.

FEBS Lett. 2002 Nov 20;531(3):489-93. doi: 10.1016/s0014-5793(02)03588-3.

PubMed ID

12435598 [ View in PubMed

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Abstract

Human gene for pancreas protein 2 (PAN2) is a novel member of the short-chain dehydrogenase/reductase gene superfamily. The properties of PAN2 protein have not yet been characterized. We present the first evidence that human PAN2 is a ubiquitously expressed microsomal enzyme that recognizes retinoids but not steroids as substrates with the apparent K(m) values between 0.08 microM and 0.4 microM. PAN2 is approximately 4-fold more efficient in the reductive than in the oxidative direction. The apparent K(m) values for NADP(+) and NADPH are 0.65 microM and 0.32 microM versus 1200 microM and 1060 microM for NAD(+) and NADH, respectively. Kinetic constants and expression pattern of PAN2 suggest that it is likely to function as a reductase in vivo and might contribute to the reduction of retinaldehyde to retinol in most human tissues.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Vitamin A	Retinol dehydrogenase 14	Protein	Humans	Unknown	Substrate	Details