Zinc binding groups for histone deacetylase inhibitors.

Article Details

Citation

Zhang L, Zhang J, Jiang Q, Zhang L, Song W

Zinc binding groups for histone deacetylase inhibitors.

J Enzyme Inhib Med Chem. 2018 Dec;33(1):714-721. doi: 10.1080/14756366.2017.1417274.

PubMed ID
29616828 [ View in PubMed
]
Abstract

Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of HDACs. An alternative ZBG is benzamide group, which features excellent inhibitory selectivity for class I HDACs. Various ZBGs have been designed and tested to improve the activity and selectivity of HDACIs, and to overcome the pharmacokinetic limitations of current HDACIs. Herein, different kinds of ZBGs are reviewed and their features have been discussed for further design of HDACIs.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Zinc chlorideHistone deacetylase 1ProteinHumans
Unknown
Cofactor
Details
Zinc chlorideHistone deacetylase 4ProteinHumans
Unknown
Cofactor
Details
Zinc sulfate, unspecified formHistone deacetylase 1ProteinHumans
Unknown
Cofactor
Details
Zinc sulfate, unspecified formHistone deacetylase 4ProteinHumans
Unknown
Cofactor
Details