Zinc binding groups for histone deacetylase inhibitors.
Article Details
- CitationCopy to clipboard
Zhang L, Zhang J, Jiang Q, Zhang L, Song W
Zinc binding groups for histone deacetylase inhibitors.
J Enzyme Inhib Med Chem. 2018 Dec;33(1):714-721. doi: 10.1080/14756366.2017.1417274.
- PubMed ID
- 29616828 [ View in PubMed]
- Abstract
Zinc binding groups (ZBGs) play a crucial role in targeting histone deacetylase inhibitors (HDACIs) to the active site of histone deacetylases (HDACs), thus determining the potency of HDACIs. Due to the high affinity to the zinc ion, hydroxamic acid is the most commonly used ZBG in the structure of HDACs. An alternative ZBG is benzamide group, which features excellent inhibitory selectivity for class I HDACs. Various ZBGs have been designed and tested to improve the activity and selectivity of HDACIs, and to overcome the pharmacokinetic limitations of current HDACIs. Herein, different kinds of ZBGs are reviewed and their features have been discussed for further design of HDACIs.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Zinc chloride Histone deacetylase 1 Protein Humans UnknownCofactorDetails Zinc chloride Histone deacetylase 4 Protein Humans UnknownCofactorDetails Zinc sulfate, unspecified form Histone deacetylase 1 Protein Humans UnknownCofactorDetails Zinc sulfate, unspecified form Histone deacetylase 4 Protein Humans UnknownCofactorDetails