Ephedrine
Article Details
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Statler AK, Maani CV, Kohli A
Ephedrine
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- PubMed ID
- 31613441 [ View in PubMed]
- Abstract
The FDA approved primary indication for ephedrine is the treatment of clinically significant hypotension perioperatively. Induction of general anesthesia and ongoing anesthesia during operative cases results in vasodilatation and hypotension requiring treatment with vasopressors.[1] It is also frequently the agent of choice for hypotension induced by spinal or epidural anesthesia. In obstetrics, sympathectomy during spinal anesthetics results in hypotension in 80% of patients [2]. Although phenylephrine selection is due to fewer effects on umbilical arterial acidity, ephedrine is a frequent choice due to less alpha-adrenergic action on the uterine vasculature which preserves uterine blood flow.[3] Also, it is sometimes given intramuscularly to achieve a longer-lasting effect.[4]
DrugBank Data that Cites this Article
- Drugs
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Ephedrine Alpha-1A adrenergic receptor Protein Humans YesAgonistDetails Ephedrine Beta-1 adrenergic receptor Protein Humans YesAgonistDetails Ephedrine Beta-2 adrenergic receptor Protein Humans YesAgonistDetails