Health implications of high dietary omega-6 polyunsaturated Fatty acids.

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Patterson E, Wall R, Fitzgerald GF, Ross RP, Stanton C

Health implications of high dietary omega-6 polyunsaturated Fatty acids.

J Nutr Metab. 2012;2012:539426. doi: 10.1155/2012/539426. Epub 2012 Apr 5.

PubMed ID

22570770 [ View in PubMed

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Abstract

Omega-6 (n-6) polyunsaturated fatty acids (PUFA) (e.g., arachidonic acid (AA)) and omega-3 (n-3) PUFA (e.g., eicosapentaenoic acid (EPA)) are precursors to potent lipid mediator signalling molecules, termed "eicosanoids," which have important roles in the regulation of inflammation. In general, eicosanoids derived from n-6 PUFA are proinflammatory while eicosanoids derived from n-3 PUFA are anti-inflammatory. Dietary changes over the past few decades in the intake of n-6 and n-3 PUFA show striking increases in the (n-6) to (n-3) ratio (~15 : 1), which are associated with greater metabolism of the n-6 PUFA compared with n-3 PUFA. Coinciding with this increase in the ratio of (n-6) : (n-3) PUFA are increases in chronic inflammatory diseases such as nonalcoholic fatty liver disease (NAFLD), cardiovascular disease, obesity, inflammatory bowel disease (IBD), rheumatoid arthritis, and Alzheimer's disease (AD). By increasing the ratio of (n-3) : (n-6) PUFA in the Western diet, reductions may be achieved in the incidence of these chronic inflammatory diseases.

DrugBank Data that Cites this Article

Drugs

Omega-6 fatty acids

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Doconexent	Sterol regulatory element-binding protein 1	Protein	Humans	Unknown	Inhibitor	Details
Omega-3 fatty acids	Sterol regulatory element-binding protein 1	Protein	Humans	Unknown	Inhibitor	Details

Drug Enzymes

Drug	Enzyme	Kind	Organism	Pharmacological Action	Actions
Omega-6 fatty acids	Arachidonate 5-lipoxygenase	Protein	Humans	Unknown	Substrate	Details
Omega-6 fatty acids	Fatty acid desaturase 1	Protein	Humans	Unknown	Substrate	Details
Omega-6 fatty acids	Fatty acid desaturase 2	Protein	Humans	Unknown	Substrate	Details
Omega-6 fatty acids	Prostaglandin G/H synthase 2	Protein	Humans	Unknown	Substrate	Details