The echinocandin micafungin: a review of the pharmacology, spectrum of activity, clinical efficacy and safety.
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Wiederhold NP, Lewis JS 2nd
The echinocandin micafungin: a review of the pharmacology, spectrum of activity, clinical efficacy and safety.
Expert Opin Pharmacother. 2007 Jun;8(8):1155-66.
- PubMed ID
- 17516879 [ View in PubMed]
- Abstract
Micafungin is a relatively broad-spectrum antifungal agent available for clinical use in the US and Japan. By inhibiting the production of beta-1,3-glucan, an essential fungal cell wall component, micafungin has reduced toxicity to mammalian cells while maintaining potent antifungal activity against many pathogenic fungi including polyene- and azole-resistant isolates. Indeed, micafungin has been shown to be efficacious in the treatment of infections caused by Candida and Aspergillus species in clinical trials without the associated toxicities of amphotericin B formulations and drug interactions that occur with the azoles. In this review, the pharmacology, spectrum of activity, clinical efficacy and safety profile of micafungin are discussed.
DrugBank Data that Cites this Article
- Drugs
- Drug Enzymes
Drug Enzyme Kind Organism Pharmacological Action Actions Micafungin Arylsulfatase A Protein Humans UnknownSubstrateDetails Micafungin Catechol O-methyltransferase Protein Humans UnknownSubstrateDetails