The lutropin/choriogonadotropin receptor, a 2002 perspective.

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Ascoli M, Fanelli F, Segaloff DL

The lutropin/choriogonadotropin receptor, a 2002 perspective.

Endocr Rev. 2002 Apr;23(2):141-74.

PubMed ID
11943741 [ View in PubMed
]
Abstract

Reproduction cannot take place without the proper functioning of the lutropin/choriogonadotropin receptor (LHR). When the LHR does not work properly, ovulation does not occur in females and Leydig cells do not develop normally in the male. Also, because the LHR is essential for sustaining the elevated levels of progesterone needed to maintain pregnancy during the first trimester, disruptions in the functions of the LHR during pregnancy have catastrophic consequences. As such, a full understanding of the biology of the LHR is essential to the survival of our species. In this review we summarize our current knowledge of the structure, functions, and regulation of this important receptor.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
CetrorelixLutropin-choriogonadotropic hormone receptorProteinHumans
Unknown
Not AvailableDetails