Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.

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Dolara P, Corte B, Ghelardini C, Pugliese AM, Cerbai E, Menichetti S, Lo Nostro A

Local anaesthetic, antibacterial and antifungal properties of sesquiterpenes from myrrh.

Planta Med. 2000 May;66(4):356-8.

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10865454 [ View in PubMed
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Abstract

We extracted, purified and characterized 8 sesquiterpene fractions from Commyphora molmol. In particular, we focused our attention on a mixture of furanodiene-6-one and methoxyfuranoguaia-9-ene-8-one, which showed antibacterial and antifungal activity against standard pathogenic strains of Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Candida albicans, with minimum inhibitory concentrations ranging from 0.18 to 2.8 micrograms/ml. These compounds also had local anaesthetic activity, blocking the inward sodium current of excitable mammalian membranes.

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