Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury.

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Radulovic M, Anand P, Korsten MA, Gong B

Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury.

J Neurogastroenterol Motil. 2015 Oct 1;21(4):494-502. doi: 10.5056/jnm15061.

PubMed ID

26424038 [ View in PubMed

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Abstract

Gastrointestinal (GI) dysmotility is a severe, and common complication in patients with spinal cord injury (SCI). Current therapeutic methods using acetylcholine analogs or laxative agents have unwanted side effects, besides often fail to have desired effect. Various ion channels such as ATP-sensitive potassium (KATP) channel, calcium ions (Ca(2+))-activated potassium ions (K(+)) channels, voltage-sensitive Ca(2+) channels and chloride ion (Cl(-)) channels are abundantly expressed in GI tissues, and play an important role in regulating GI motility. The release of neurotransmitters from the enteric nerve terminal, innervating GI interstitial cells of Cajal (ICC), and smooth muscle cells (SMC), causes inactivation of K(+) and Cl(-) channels, increasing Ca(2+) influx into cytoplasm, resulting in membrane depolarization and smooth muscle contraction. Thus, agents directly regulating ion channels activity either in ICC or in SMC may affect GI peristalsis and would be potential therapeutic target for the treatment of GI dysmotility with SCI.

DrugBank Data that Cites this Article

Drugs

Trimebutine

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Trimebutine	Calcium-activated potassium channel (Protein Group)	Protein group	Humans	Yes	Inhibitor	Details
Trimebutine	Voltage-dependent L-type calcium channel (Protein Group)	Protein group	Humans	Yes	Inhibitor	Details
Trimebutine	Voltage-dependent T-type calcium channel (Protein Group)	Protein group	Humans	Unknown	Activator	Details