Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.

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Kim BY, Ahn JB, Lee HW, Kang SK, Lee JH, Shin JS, Ahn SK, Hong CI, Yoon SS

Synthesis and biological activity of novel substituted pyridines and purines containing 2,4-thiazolidinedione.

Eur J Med Chem. 2004 May;39(5):433-47.

PubMed ID
15110969 [ View in PubMed
]
Abstract

A series of substituted pyridines and purines containing 2,4-thiazolidinedione were designed and synthesized from their corresponding pyridines and purines. These synthesized compounds (entry no. 6a-d, 12a-e, 18a-d, 23a-c) were evaluated for their effect on triglyceride accumulation in 3T3-L1 cells in vitro and their hypoglycemic and hypolipidemic activity in the genetically diabetic KKA(y) mice in vivo. On the basis of their biological activities, 5-(4-[2-[N-methyl-(5-phenyl-pyridin-2-yl)amino]ethoxy]benzyl)thiazolidine-2,4-dio ne (6d) was selected as a candidate for further pharmacological studies.

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