[Behavioral and radioreceptor analysis of viloxazine stereoisomers].
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Danchev ND, Rozhanets VV, Zhmurenko LA, Glozman OM, Zagorevskii VA
[Behavioral and radioreceptor analysis of viloxazine stereoisomers].
Biull Eksp Biol Med. 1984 May;97(5):576-8.
- PubMed ID
- 6326891 [ View in PubMed]
- Abstract
The differences in the pharmacological effects of R(+)- and S(-)-isomers of the atypical antidepressant viloxazin were discovered in two behavioral models. The S(-)-isomer appeared 5 times as active as the R(+)-isomer under acute administration. In chronic administration, (15 days), the R(+)-isomer appeared ineffective. Comparison of the affinity of the racemate, R(+) and S(-)-isomers for alpha 1-, alpha 2- and beta-adrenoreceptors, as well as for serotonin, C1, benzodiazepine, imipramine and dopamine receptors did not demonstrate any stereospecificity of viloxazin isomers. It is assumed that some other receptors (histamine, acetylcholine) present the targets for the pharmacological action of viloxazin or the latter one has, like zimelidin , specific binding sites of its own.