Antihypertensives acting by a peripheral mechanism

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Francis JE

Antihypertensives acting by a peripheral mechanism

ACS Symposium Series. 1976 June 01;27:55-79.

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Abstract

The efforts of medicinal researchers in trying to find antihypertensive agents working by a peripheral mechanism arise from the expectation that these agents will effect good blood pressure control without the central nervous system side effects which are observed to some extent with every marketed agent to date which has a strong central component in its mechanism of action. Since antihypertensive therapy, except in emergency treatment, requires drug treatment every day for a long period of time, perhaps decades, it is important that the mental and physical capabilities of the patient be impaired as little as possible. This is particularly important in those cases where the hypertensive patient feels well despite his condition.

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