Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination.
Article Details
- CitationCopy to clipboard
Kyei S, Nketsiah AA, Asiedu K, Awuah A, Owusu-Ansah A
Onset and duration of cycloplegic action of 1% cyclopentolate - 1% tropicamide combination.
Afr Health Sci. 2017 Sep;17(3):923-932. doi: 10.4314/ahs.v17i3.36.
- PubMed ID
- 29085421 [ View in PubMed]
- Abstract
PURPOSE: To study the time course (onset, time and duration of maximal cycloplegia, and the full duration) of cycloplegic action of 1% Cyclopentolate - 1% Tropicamide. METHODS: Seventy-seven students, aged 15-24 years were purposively sampled from the University of Cape Coast and Cape Coast Technical Institute. Subjective near addition (ADD) determination and pupil diameter measurement before and after a drop of the test agent (1% Cyclopentolate - 1% Tropicamide combination in the right eye) and the control (1% Cyclopentolate in the left eye) were performed. Measurements of subjective near ADD and pupil diameter were made after the initial reading at 5 minutes interval for the first hour and every 30 minutes for the next 7 hours for each participant. Time of onset, time of peak cycloplegia, duration of peak cycloplegia and duration of total cycloplegic effect was indirectly determined. RESULTS: 1% Cyclopentolate - 1% Tropicamide combination had rapid onset of cycloplegia (5-10 minutes), shorter time of maximal cycloplegia (55 versus 90 minutes), and recovery (7 versus >/= 8hours) in the majority (79.2%) of subjects. CONCLUSION: Cyclopentolate -Tropicamide combination was comparable to Cyclopentolate in depth of cycloplegia produced, and clinically superior to 1% Cyclopentolate in rapidity of cycloplegic onset, time of maximal cycloplegia and recovery from cycloplegia.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Cyclopentolate Muscarinic acetylcholine receptor M1 Protein Humans YesAntagonistDetails