Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia.

Article Details

Citation

Kim DH, Maneen MJ, Stahl SM

Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia.

Neurotherapeutics. 2009 Jan;6(1):78-85. doi: 10.1016/j.nurt.2008.10.020.

PubMed ID
19110200 [ View in PubMed
]
Abstract

Attempts to develop selective ("magic bullet") drugs for the treatment of schizophrenia have been frustrated by the complex etiology of the disease. The symptomatology of schizophrenia does not appear to arise from a single neurobiological entity, but rather may be derived from pathology at one or more receptor types. This has prompted multifactorial approaches to the development of new therapeutics, as embodied by polypharmacy and an alternative (or augmentative) strategy known as "intramolecular polypharmacy," in which a single drug possesses the capacity to affect multiple receptor types. Atypical antipsychotics are a well-known example of this approach; each atypical possesses a unique portfolio of activities at receptors that may contribute to therapeutic effects (as well as side effects). In this article we present a discussion of some of the receptor targets that are currently thought to mediate symptoms of schizophrenia, as well as their possible implications for the design of future multifunctional antipsychotics.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
Promazine5-hydroxytryptamine receptor 2AProteinHumans
Unknown
Antagonist
Details
Promazine5-hydroxytryptamine receptor 2CProteinHumans
Unknown
Antagonist
Details
PromazineAlpha-1A adrenergic receptorProteinHumans
Unknown
Antagonist
Details
PromazineDopamine D2 receptorProteinHumans
Yes
Antagonist
Details
PromazineHistamine H1 receptorProteinHumans
Unknown
Antagonist
Details
PromazineMuscarinic acetylcholine receptor M1ProteinHumans
Unknown
Antagonist
Details
Propiomazine5-hydroxytryptamine receptor 2AProteinHumans
Unknown
Antagonist
Details
Propiomazine5-hydroxytryptamine receptor 2CProteinHumans
Unknown
Antagonist
Details
PropiomazineAlpha-1A adrenergic receptorProteinHumans
Unknown
Antagonist
Details
PropiomazineDopamine D2 receptorProteinHumans
Unknown
Antagonist
Details
PropiomazineHistamine H1 receptorProteinHumans
Yes
Antagonist
Details
PropiomazineMuscarinic acetylcholine receptor (Protein Group)Protein groupHumans
Unknown
Antagonist
Details