Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia.
Article Details
- CitationCopy to clipboard
Kim DH, Maneen MJ, Stahl SM
Building a better antipsychotic: receptor targets for the treatment of multiple symptom dimensions of schizophrenia.
Neurotherapeutics. 2009 Jan;6(1):78-85. doi: 10.1016/j.nurt.2008.10.020.
- PubMed ID
- 19110200 [ View in PubMed]
- Abstract
Attempts to develop selective ("magic bullet") drugs for the treatment of schizophrenia have been frustrated by the complex etiology of the disease. The symptomatology of schizophrenia does not appear to arise from a single neurobiological entity, but rather may be derived from pathology at one or more receptor types. This has prompted multifactorial approaches to the development of new therapeutics, as embodied by polypharmacy and an alternative (or augmentative) strategy known as "intramolecular polypharmacy," in which a single drug possesses the capacity to affect multiple receptor types. Atypical antipsychotics are a well-known example of this approach; each atypical possesses a unique portfolio of activities at receptors that may contribute to therapeutic effects (as well as side effects). In this article we present a discussion of some of the receptor targets that are currently thought to mediate symptoms of schizophrenia, as well as their possible implications for the design of future multifunctional antipsychotics.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Promazine 5-hydroxytryptamine receptor 2A Protein Humans UnknownAntagonistDetails Promazine 5-hydroxytryptamine receptor 2C Protein Humans UnknownAntagonistDetails Promazine Alpha-1A adrenergic receptor Protein Humans UnknownAntagonistDetails Promazine Dopamine D2 receptor Protein Humans YesAntagonistDetails Promazine Histamine H1 receptor Protein Humans UnknownAntagonistDetails Promazine Muscarinic acetylcholine receptor M1 Protein Humans UnknownAntagonistDetails Propiomazine 5-hydroxytryptamine receptor 2A Protein Humans UnknownAntagonistDetails Propiomazine 5-hydroxytryptamine receptor 2C Protein Humans UnknownAntagonistDetails Propiomazine Alpha-1A adrenergic receptor Protein Humans UnknownAntagonistDetails Propiomazine Dopamine D2 receptor Protein Humans UnknownAntagonistDetails Propiomazine Histamine H1 receptor Protein Humans YesAntagonistDetails Propiomazine Muscarinic acetylcholine receptor (Protein Group) Protein group Humans UnknownAntagonistDetails