Modulation of signal transduction by vitamin E.

Article Details

Citation

Zingg JM

Modulation of signal transduction by vitamin E.

Mol Aspects Med. 2007 Oct-Dec;28(5-6):481-506. doi: 10.1016/j.mam.2006.12.009. Epub 2007 Jan 12.

PubMed ID
17320164 [ View in PubMed
]
Abstract

The ability of vitamin E to modulate signal transduction and gene expression has been observed in numerous studies; however, the detailed molecular mechanisms involved are often not clear. The eight natural vitamin E analogues and synthetic derivatives affect signal transduction with different potency, possibly reflecting their different ability to interact with specific proteins. Vitamin E modulates the activity of several enzymes involved in signal transduction, such as protein kinase C, protein kinase B, protein tyrosine kinases, 5-, 12-, and 15-lipoxygenases, cyclooxygenase-2, phospholipase A2, protein phosphatase 2A, protein tyrosine phosphatase, and diacylglycerol kinase. Activation of some these enzymes after stimulation of cell surface receptors with growth factors or cytokines can be normalized by vitamin E. At the molecular level, the translocation of several of these enzymes to the plasma membrane is affected by vitamin E, suggesting that the modulation of protein-membrane interactions may be a common theme for vitamin E action. In this review the main effects of vitamin E on enzymes involved in signal transduction are summarized and the possible mechanisms leading to enzyme modulation evaluated. The elucidation of the molecular and cellular events affected by vitamin E could reveal novel strategies and molecular targets for developing similarly acting compounds.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
alpha-Tocopherol succinateDiacylglycerol kinase (Protein Group)Protein groupHumans
Unknown
Not AvailableDetails
Vitamin ESerine/threonine-protein phosphatase 2A catalytic subunit alpha isoformProteinHumans
Unknown
Not AvailableDetails
Vitamin ESerine/threonine-protein phosphatase 2A catalytic subunit beta isoformProteinHumans
Unknown
Not AvailableDetails