Anti-estrogenic activity of fifty chemicals evaluated by in vitro assays.

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Jung J, Ishida K, Nishihara T

Anti-estrogenic activity of fifty chemicals evaluated by in vitro assays.

Life Sci. 2004 May 7;74(25):3065-74.

PubMed ID
15081572 [ View in PubMed
]
Abstract

We examined the anti-estrogenic activity of 50 chemicals by the yeast two-hybrid assay and detected the activity of hexachlorophene, pentachlorophenol, and vitamin K3 (menadione), in that order. These chemicals were also observed to inhibit the transcriptional activity of 17beta-estradiol in a reporter gene assay system using MCF-7 cells, estrogen receptor-positive breast cancer cells, and to bind directly to estrogen receptor alpha in a competitive binding assay system, although the order of the activity was slightly different among the 3 assays. These findings suggested that three of fifty chemicals could inhibit estrogen activity by competitive binding with 17beta-estradiol to the estrogen receptor.

DrugBank Data that Cites this Article

Drug Targets
DrugTargetKindOrganismPharmacological ActionActions
HexachloropheneEstrogen receptor alphaProteinHumans
Unknown
Not AvailableDetails