Fatty acids bound to vitamin D-binding protein (DBP) from human and bovine sera.

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Ena JM, Esteban C, Perez MD, Uriel J, Calvo M

Fatty acids bound to vitamin D-binding protein (DBP) from human and bovine sera.

Biochem Int. 1989 Jul;19(1):1-7.

PubMed ID
2673244 [ View in PubMed
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Abstract

Human and bovine vitamin D-binding protein (DBP) have been isolated from serum by a method that does not involve denaturing steps. This method includes Cibacron Blue-Sepharose chromatography, gel filtration, DEAE-Sephadex chromatography and albumin immunoadsorption. Analysis of fatty acids bound to the isolated human and bovine DBP showed molar ratios of fatty acid to protein of 0.4 and 1.3 respectively meanwhile human and bovine albumin have bound 1.8 and 1.5 moles per mol respectively. Most of fatty acids bound to human and bovine DBP are monounsaturated and saturated, mainly oleic and palmitic acids, which together account for 50% of the total of fatty acids in both species. By contrast, polyunsaturated fatty acids represented a minor component, less than 5%.

DrugBank Data that Cites this Article

Drug Carriers
DrugCarrierKindOrganismPharmacological ActionActions
Oleic AcidVitamin D-binding proteinProteinHumans
Unknown
Not AvailableDetails