Dopamine receptor blockade and the neuroleptics, a crystallographic study.

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Horn AS, Post ML, Kennard O

Dopamine receptor blockade and the neuroleptics, a crystallographic study.

J Pharm Pharmacol. 1975 Aug;27(8):553-63. doi: 10.1111/j.2042-7158.1975.tb09506.x.

PubMed ID

239169 [ View in PubMed

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Abstract

The X-ray structures of 12 drugs of the tricyclic class having varying pharmacological profiles have been examined in detail in an attempt to rationalize the known structure-activity relations of neuroleptic drugs with respect to their ability to block dopamine receptors in the brain. Further evidence is presented in support of the theory that the neuroleptics are able to block dopamine receptors because of a conformational complementarity between certain portions of these drugs and dopamine.

DrugBank Data that Cites this Article

Drug Targets

Drug	Target	Kind	Organism	Pharmacological Action	Actions
Triflupromazine	Dopamine D1 receptor	Protein	Humans	Yes	Antagonist	Details
Triflupromazine	Dopamine D2 receptor	Protein	Humans	Yes	Antagonist	Details