Interactions of metals and Apolipoprotein E in Alzheimer's disease.
Article Details
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Xu H, Finkelstein DI, Adlard PA
Interactions of metals and Apolipoprotein E in Alzheimer's disease.
Front Aging Neurosci. 2014 Jun 12;6:121. doi: 10.3389/fnagi.2014.00121. eCollection 2014.
- PubMed ID
- 24971061 [ View in PubMed]
- Abstract
Alzheimer's disease (AD) is the most common form of dementia, which is characterized by the neuropathological accumulation of extracellular amyloid plaques and intracellular neurofibrillary tangles (NFTs). Clinically, patients will endure a gradual erosion of memory and other higher order cognitive functions. Whilst the underlying etiology of the disease remains to be definitively identified, a body of work has developed over the last two decades demonstrating that AD plasma/serum and brain are characterized by a dyshomeostasis in a number of metal ions. Furthermore, these metals (such as zinc, copper and iron) play roles in the regulation of the levels of AD-related proteins, including the amyloid precursor protein (APP) and tau. It is becoming apparent that metals also interact with other proteins, including apolipoprotein E (ApoE). The Apolipoprotein E gene (APOE) is critically associated with AD, with APOE4 representing the strongest genetic risk factor for the development of late-onset AD. In this review we will summarize the evidence supporting a role for metals in the function of ApoE and its consequent role in the pathogenesis of AD.
DrugBank Data that Cites this Article
- Drug Targets
Drug Target Kind Organism Pharmacological Action Actions Copper Apolipoprotein E Protein Humans UnknownNot Available Details