Dependence of renal clearance on urine flow: a mathematical model and its application.

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Tang-Liu DD, Tozer TN, Riegelman S

Dependence of renal clearance on urine flow: a mathematical model and its application.

J Pharm Sci. 1983 Feb;72(2):154-8. doi: 10.1002/jps.2600720215.

PubMed ID
6834253 [ View in PubMed
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Abstract

A mathematical model is developed to explain the dependence of renal clearance on urine flow rate. The model is tested using human data from the literature on compounds that are neither secreted nor reabsorbed by active or pH-sensitive mechanisms. The physiologically derived model explains and predicts the relationship between renal clearance and urine flow for a broad spectrum of compounds (i.e., butabarbital, chloramphenicol, creatinine, ethanol, theophylline, and urea) for which appropriate data are available.

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